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Exploration of the relationship between these genes in the model and AML. (A) Analysis of differential expressions of these four genes between AML and healthy patients (a) , high-, and low-risk groups (b) , respectively. (B) Assessment of their correlation with monocytes. (C) Survival analysis of HCP5 in the GSE37642 dataset showed that its expression was associated with prognosis. (D,E) CCK8 results showed that silencing of HCP5 significantly affected the proliferation of KG-1 cells. (F,G) ATRA (1 μM) in combination with <t>RAD001</t> (10 nM) strikingly downregulated the expression of HCP5 and inhibited cell growth, especially in HCP5-silenced cells.
Rad001 Everolimus, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rad001 everolimus - by Bioz Stars, 2026-03
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Exploration of the relationship between these genes in the model and AML. (A) Analysis of differential expressions of these four genes between AML and healthy patients (a) , high-, and low-risk groups (b) , respectively. (B) Assessment of their correlation with monocytes. (C) Survival analysis of HCP5 in the GSE37642 dataset showed that its expression was associated with prognosis. (D,E) CCK8 results showed that silencing of HCP5 significantly affected the proliferation of KG-1 cells. (F,G) ATRA (1 μM) in combination with RAD001 (10 nM) strikingly downregulated the expression of HCP5 and inhibited cell growth, especially in HCP5-silenced cells.

Journal: Frontiers in Genetics

Article Title: Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia

doi: 10.3389/fgene.2022.959109

Figure Lengend Snippet: Exploration of the relationship between these genes in the model and AML. (A) Analysis of differential expressions of these four genes between AML and healthy patients (a) , high-, and low-risk groups (b) , respectively. (B) Assessment of their correlation with monocytes. (C) Survival analysis of HCP5 in the GSE37642 dataset showed that its expression was associated with prognosis. (D,E) CCK8 results showed that silencing of HCP5 significantly affected the proliferation of KG-1 cells. (F,G) ATRA (1 μM) in combination with RAD001 (10 nM) strikingly downregulated the expression of HCP5 and inhibited cell growth, especially in HCP5-silenced cells.

Article Snippet: RAD001 (everolimus) and all-trans retinoic acid (ATRA) were purchased from APExBIO (Houston, USA) and Sigma Chemical Co. Ltd. (St. Louis, MO), respectively.

Techniques: Expressing